ESMO clinical recommendations: a practical guide for medical oncologists

Management of cancer pain: ESMO clinical recommendations.

Over 80% of cancer patients with advanced metastatic disease suffer pain caused mostly by direct tumor infiltration. Pain undermines quality of life considerably and is a clinically important indicator of tumor progression. Cancer pain may be acute or chronic and should be addressed accordingly. Approximately 20% of pain in cancer patients may be attributed to the effects of surgery, radiothera...

Statistics for Medical Students: a Practical Guide

(Pp. 52. 9s.) Hong Kong UnivCrsity Press. London: Oxford University Press, 19%2. THIS book is an introduction to the use of statistical methods in the analysis of snmall samples of data. The author describes, with simple numerical examples, the arithmetic steps in computing averages, measures of dispersion, corielation coefficients, including partial coefficients vith one variable held constant...

BRCA in breast cancer: ESMO clinical recommendations.

Familial susceptibility to breast cancer accounts for 25% of all breast cancer cases. In familial breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53 and PTEN genes account for 5–10% of breast and ovarian cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably between ethnic groups and geographical areas. Populationspecific mutations have been described in Ice...

A practical guide for medical statisticians

Since the early 1980s, a bewildering array of methods for constructing bootstrap con"dence intervals have been proposed. In this article, we address the following questions. First, when should bootstrap con"dence intervals be used. Secondly, which method should be chosen, and thirdly, how should it be implemented. In order to do this, we review the common algorithms for resampling and methods f...

A Practical Guide for Medical Teachers.